Features How it works Changelog Pricing FAQ
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v2.4 just released — see changelog

Analyze genetic variants in seconds

Upload your VCF file and get a clear, structured overview of genetic variants with priority indicators and human-readable explanations.

Download App — Free See it in action
Runs locally · No data upload · Works offline · macOS · Windows · Linux
VariantTriage — sample_wes_analysis.vcf
sample_wes_analysis.vcf
1,248 variants parsed · 127 KB
3 High
9 Medium
41 Low
GenePositionTypePriorityNote
RPGRchrX:38,152,229MissenseHighKnown pathogenic variant
RHOchr3:14,182,883MissenseHighLikely pathogenic
USH2Achr1:216,595,579Splice siteMediumVariant of interest, VUS
PRPF31chr19:17,942,600SynonymousLowLikely benign
TULP1chr6:35,517,208IntronicLowBenign, no known effect
0
VCF files analyzed
0
Analysis accuracy
0
Supported gene databases
0
Average analysis time

Features

Everything you need.
Nothing you don't.

01

Fast VCF analysis

Load any standard VCF file — GATK, DeepVariant, Illumina, 23andMe — and get structured results in seconds.

02
🎯

Clear prioritization

Variants are automatically triaged into High, Medium, and Low tiers. You always know where to look first.

03
📖

Human-readable output

No cryptic annotations. Each variant ships with a plain explanation and direct links to ClinVar and OMIM.

04
🔒

100% local processing

All analysis runs on your machine. No internet required for core features. Your files never leave your device.

05
📊

Built-in visualizations

Chromosome maps, severity breakdowns, gene frequency charts — rendered instantly without external tools.

06
📄

Export anywhere

Export clean PDF reports or CSV tables. Share with colleagues or keep as structured documentation.

Workflow

From raw data
to clear insight.

Four steps. Under sixty seconds. No configuration required.

01
Load your VCF file
Drag-and-drop or browse. Supports all major VCF formats and sequencing sources.
02
Review the structured table
Variants are parsed, annotated, and displayed in a clean, sortable interface with full details on click.
03
Focus on priority variants
Filter by tier, gene, chromosome, or type. Click any variant for its full annotation and references.
04
Export your results
Download a clean PDF report or structured CSV. Ready for further analysis or documentation.
$varianttriage load sample_wes.vcf
Parsing VCF format... GATK v4.4.0
✓ 1,248 variants loaded in 0.8s
✓ Priority scoring complete
$varianttriage report --format pdf
✓ Report exported: report_2025.pdf
$
High priority
3
Medium
9
Low
41

Changelog

What's new in VariantTriage.

Every release, documented. We ship improvements every few weeks.

v2.4 June 12, 2025 New
  • DNA visualizer — New 3D-style chromosome map for understanding variant distribution across the genome at a glance.
  • Dark / Light theme — Full theme switching with smooth transitions. Your preference is saved across sessions.
  • Batch export — Export multiple analyses at once as a combined PDF or individual files.
  • ClinVar cache — ClinVar lookups are now cached locally for 7 days, dramatically reducing repeat network requests.
v2.3 April 3, 2025 Improved
  • 50% faster parsing — VCF parser rewritten with streaming I/O. Large files (500k+ variants) now load in under 2 seconds.
  • Family tree editor — Visual pedigree builder for tracking variant inheritance patterns across family members.
  • Symptom tracker — Log and track symptom progression over time with exportable CSV output.
v2.2 February 18, 2025 Fix
  • SnpEff ANN= format — Fixed parsing for SnpEff annotated VCFs with multi-allelic ANN fields.
  • OMIM deep links — Variant cards now link directly to the relevant OMIM phenotype entry, not just the gene page.
  • Windows Hi-DPI — Fixed blurry rendering on Windows with 4K displays at 150%+ scaling.
v2.1 December 9, 2024 New
  • PDF report engine — Professional PDF reports with full variant tables, charts, and customizable header / clinic details.
  • ClinVar live lookup — Optional real-time ClinVar queries for any selected variant, with significance history.

Trusted by researchers

Used across leading institutions.

From independent researchers to university labs — VariantTriage is built for serious work.

🧬
GenomeLab
🔬
BioResearch EU
⚗️
VarMed Institute
🏛️
UniGen Sciences
🧪
SequenceCore

"VariantTriage cut our variant review time from hours to minutes. The priority triage is exactly what we needed — no noise, just signal."

AR
Dr. A. Reinholt
Genomics Researcher, BioResearch EU

"Finally a tool that respects data privacy. Everything stays local, the interface is clean, and the output is actually readable by non-bioinformaticians."

MK
M. Kowalski
Lab Director, SequenceCore

"The comparison table alone is worth it. I can finally show non-technical colleagues exactly what we're looking at, without a 30-minute explanation."

SL
S. Laurent
Independent Researcher, Paris

Comparison

Why choose VariantTriage?

See how we compare to typical alternatives for variant review workflows.

FeatureVariantTriageIGV / Generic viewersCloud-based tools
Instant priority triagePartial
100% local processing
Human-readable explanationsPartial
No setup / no CLI required
PDF & CSV exportPartial
No subscription fee
Works offline

Why VariantTriage

Built for researchers
who value clarity.

🚀

No complex setup

Download and run. No configuration files, no dependency management, no command line knowledge required.

🔒

No data upload

Your VCF files are processed entirely on your local machine. Nothing is ever transmitted to any server.

📡

No cloud dependency

Works completely offline for all core analysis. ClinVar lookups are optional and clearly indicated when used.

Designed for speed

From raw VCF to prioritized, readable output in under 60 seconds. No queue, no wait, no friction.

Pricing

Simple, one-time pricing.

No subscriptions. No recurring fees. Pay once, use forever on any machine.

Free
0

Try the full interface with a demo dataset. No account needed.

  • Demo VCF dataset included
  • Full interface access
  • All visualizations
  • Export disabled
  • Custom VCF files
Try Demo
Lab
49one-time

For small teams, shared research environments, and lab groups.

  • Everything in Pro
  • Up to 5 seats
  • Priority support
  • Batch VCF processing
  • All future updates
Buy Lab — €49

FAQ

Common questions.

Everything you need to know before downloading.

Is VariantTriage free to use?
Yes — you can download and use VariantTriage for free with our included demo dataset. To analyze your own VCF files and unlock export, you'll need a Pro license (€19, one-time).
Does my data get uploaded anywhere?
No. All core processing happens entirely on your local machine. Your VCF files never leave your device. Optional ClinVar lookups only send gene identifiers — never your raw variant data.
What VCF formats are supported?
VariantTriage supports all standard VCF formats including GATK, DeepVariant, Illumina DRAGEN, 23andMe raw data, and BCFtools output. Both VCF 4.1 and 4.2 are supported.
Is this a medical or diagnostic tool?
No. VariantTriage is strictly a research tool for organizing and reviewing genetic variant data. It is not intended for medical or diagnostic use. All results require professional interpretation.
Which operating systems are supported?
VariantTriage runs on macOS (11+), Windows 10/11, and Ubuntu/Debian Linux. All platforms receive the same features and updates simultaneously.
Can I use it without internet?
Yes, fully. All core analysis — parsing, annotation, prioritization, visualization, and export — works completely offline. Internet is only needed for optional ClinVar/OMIM lookups, clearly marked in the UI.
What does the Lab license include?
The Lab license (€49) includes everything in Pro, up to 5 seats, priority support, batch processing of multiple VCF files, and all future updates. Designed for shared lab environments.
Do you offer refunds?
Yes. We offer a 30-day no-questions-asked refund policy. If VariantTriage isn't right for your workflow, contact us within 30 days of purchase for a full refund.

Get started today

Start analyzing
your data today.

Join researchers worldwide who use VariantTriage to work through variant data faster and with more clarity.

Download VariantTriage View pricing
For Research Use Only This software is not intended for medical or diagnostic use. VariantTriage is a research tool for organizing and reviewing genetic variant data. Results require professional interpretation and should not be used as the basis for any clinical decisions.